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KMID : 0438219780150010047
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Korea University Medical Journal
1978 Volume.15 No. 1 p.47 ~ p.51
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The Effect of Potassium Ion on the Oxidative Metabolism of Rat Brain Slices
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Abstract
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This investigation was undertaken to clearify the mechanism of the stimulated respiration caused by K+ in brain tissue, using Warburg´s manometric apparatus. The oxygen consumption of the -slices of cerebral cortex, cerebellum of rat was studied in Krebs-Ringer bicarbonate medium (pH 7.4) under 100% oxygen phase.
The addition of 140 mM KCl in medium stimulated remarkably oxygen consumption rate in brain tissue. while the addition of 120 mM sucrose were not stimulated.
These results indicated that the K load and increased metabolism could reflects an increased energy -expenditure involved active 13a-X pump either by neurons or by glia cells or both.
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